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San Francisco heads into the regular season with the fourth-toughest strength of schedule based on their opponents 2019 win percentages (.527). They could be without one of their best linebackers in Leighton Vander Esch once again. 1. The 49ers are scheduled to play six teams coming off of playoff appearances in 2019. Cooper Kupp had a career high seven catches for 220 yards in the Rams' victory. One woman made sure to get in a final, parting shot (…)Fore in golf means look out. MosleyWeek 3 @ New York Giants 10:00 a.m. PT (Fox)Week 5 vs. Miami Dolphins 1:05 p.m. PT (Fox)Philadelphia Eagles defensive tackle Fletcher CoxMiami Dolphins cornerback Xavien HowardWeek 1 vs. Arizona Cardinals 1:25 p.m. PT (Fox)Week 16 @ Arizona Cardinals TBDWashington Football Team wide receiver Terry McLaurinSan Francisco tied for the third-most representatives on the yearly countdown voted on solely by the players themselves.Seattle Seahawks linebacker Bobby WagnerNew England Patriots cornerback Stephon GilmoreBuffalo Bills quarterback Josh AllenWeek 9 vs. Green Bay Packers 5:20 p.m. (Fox/NFL Network/Amazon Prime)NFC West, Buffalo Bills, Green Bay Packers, Miami Dolphins, Philadelphia Eagles, Washington RedskinsGreen Bay Packers wide receiver Davante AdamsWeek 15 @ Dallas Cowboys 5:20 p.m. PT (NBC)Los Angeles Rams quarterback Jared GoffDallas Cowboys running back Ezekiel ElliottSeattle Seahawks cornerback Shaquill GriffinLos Angeles Rams head coach Sean McVayArizona Cardinals cornerback Patrick PetersonBuffalo Bills cornerback Tre'Davious WhiteNew York Giants head coach Joe JudgeHere's the full list of home and road opponents for the 49ers in 2020.New York Giants defensive lineman Dexter LawrenceWeek 10 @ New Orleans Saints 1:25 p.m. PT (Fox)Seattle Seahawks head coach Pete CarrollSeattle Seahawks quarterback Russell WilsonPhiladelphia Eagles head coach Doug PedersonWeek 8 @ Seattle Seahawks 1:25 p.m. PT (Fox)Week 13 vs. Buffalo Bills 5:15 p.m. PT (ESPN)Latest news on San Francisco's roster moves, Richard Sherman and Nick Bosa are latest 49ers announced on NFL's Top 100, John Lynch gives updates on the team heading into training camp.Philadelphia Eagles quarterback Carson WentzWeek 17 vs. Seattle Seahawks 1:25 p.m. (Fox)Los Angeles Rams defensive tackle Aaron DonaldDallas Cowboys head coach Mike McCarthyArizona Cardinals quarterback Kyler MurrayDallas Cowboys linebacker Jaylon SmithNew Orleans Saints wide receiver Michael ThomasSan Francisco's tight end cracks the Top 10 voted on by current NFL players, as the fifth and final member of the 49ers to make the yearly countdown.Arizona Cardinals head coach Kliff KingsburyArizona Cardinals linebacker Chandler JonesNew Orleans Saints head coach Sean PaytonLos Angeles Rams wide receiver Cooper KuppThe San Francisco 49ers 2020 opponents have been set. Though Danny Amendola was the only Lions receiver to make the 50% threshold, both Marvin Jones and Kenny Golladay were highly efficient when tasked to move inside. 1 WR for the Rams now that Brandin Cooks and Todd Gurley are no longer on the team. Cooper Kupp profile page, biographical information, injury history and news Jun 27, 2020 ... Week 12: vs San Francisco 49ers. Kupp is the sure No.