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The Chemistry, Properties and Tests of Precious Stones. — opalescent , adj . Arginine suppresses opalescence and liquid-liquid phase separation in IgG solutions. The coloration of solution is also defined in the European Pharmacopeia. Even when the opalescence is very small, when the solution is viewed at right ..." 2. The coloration of solution is also defined in the European Pharmacopeia. Increased solution opalescence can be attributed to attractive protein–protein interactions (PPIs). © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.Opalescence indicates physical instability of a formulation because of the presence of aggregates or liquid-liquid phase separation in solution and has been reported for monoclonal antibody (mAb) formulations. It is a helpful parameter that can relate to aggregation, but also other solution phenomena like liquid phase separation. Author information: (1)Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan. Temperature dependence of opalescence suggests that thermodynamic contribution to opalescence is significant and Tcloud can be utilized as a potential tool to assess attractive interactions in solution. Hack for Soap Scum Removal: Clean your shower and tub in less than 6 minutes - Duration: 22:47. The mAb molecule studied here shows a unique property of high opalescence because of liquid-liquid phase separation. Increased solution opalescence can be attributed to attractive protein-protein interactions (PPIs). Coloration in protein products can relate to concentration, type of formulation, but also process- or product-related degradants or contaminants. Charges on the molecules were calculated using zeta potential measurements. "opalescence" is self-suggesting as to its origin, which is the "noble" or "precious" opal; this radiates brilliant and rapidly changing ... all blending with, and coming out of, a curious silky and milky whiteness, which is altogether characteristic. Opalescence - definition of opalescence by The Free Dictionary . This service is more advanced with JavaScript available“Appearance” is an analytical test often found in specifications of protein drug products. Solution viscosity is of utmost importance for manufacturing as well as administration of biologics at higher concentration. Opalescence indicates physical instability of a formulation because of the presence of aggregates or liquid–liquid phase separation in solution and has been reported for monoclonal antibody (mAb) formulations. Finally, aggregates and particles can arise as a result of degradation pathways and subvisible and visible particles in parenteral preparations also have to comply with related pharmacopoeial requirements.Over 10 million scientific documents at your fingertips In this study, opalescence measurements are correlated to PPIs measured in diluted and concentrated solutions using light scattering (kD ) and high-frequency rheology (G'), respectively. However, appearance can mean many different things, including dosage form (liquid, dried), color (coloration of solution, color of cake), cake appearance (in case of a lyophilisate), opalescence, or turbidity, and—in some cases—even visible particles. Opalescence indicates physical instability of a formulation because of the presence of aggregates or liquid-liquid phase separation in solution and has been reported for monoclonal antibody (mAb) formulations. But given the nature of biologics and the analytical methods used for assessing solubility often do not yield any practically relevant information. “Maximum solubility” is a parameter that has been previously evaluated for proteins. Techniques including light scattering, AUC, or membrane osmometry are routinely employed to measure PPIs in dilute solutions, whereas opalescence is seen at relatively higher concentrations, where both long- and short-range forces contribute to overall PPIs. All Purpose Mom Recommended for you es′cence n. the quality of being opallike, or milkily iridescent. Opalescence, respectively, solution clarity can be measured as defined by the European Pharmacopeia. Oki S(1), Nishinami S(1), Shiraki K(2). Définitions de opalescent, synonymes, antonymes, dérivés de opalescent, dictionnaire analogique de opalescent (français)