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Prior to 1822, yellow fever attacked cities as far north as Boston, but after 1822 it was restricted to the south. During the hot, humid summer of 1793, thousands of Philadelphians got horribly sick, suffering from fevers and chills, jaundiced skin, stomach pains and vomit tinged black with blood.Twice a week we compile our most fascinating features and deliver them straight to you.However the disease had arrived, Philadelphians in 1793 desperately sought to avoid getting it. Port cities were the primary targets, but the disease occasionally spread up the Mississippi River system in the 1800s. They began keeping their distance from each other and avoided shaking hands. Rush lost his sister to the disease and even fell ill himself, although he recovered. But Rush, the country’s most prominent medical professional and a signer of the Declaration of Independence, stayed behind, working tirelessly to treat rich and poor patients alike. ↩ Lindsey N, et al. Drug Des Devel Ther 2016; 10: 3345–53. Recent white immigrants to southern port cities were the most vulnerable; local whites and blacks enjoyed considerable resistance. The disease was not indogenous; epidemics were imported by ship from the Caribbean. Major yellow fever epidemics, 1808-1905 Year Place Deaths Mortality and Remarks Year Place Deaths Mortality and Remarks 1808 St Marys, GA 45 9% 1849 Charleston 125 1811 New Orleans 500 Mobile 50 Pensacola New Orleans 737 1817 Charleston 272 1852 Charleston 310 0.7% New Orleans 800 New Orleans 415 Savannah 19 1818 Charleston 115 New Orleans 115 1853 Baton Rouge, LA 200 … Yellow fever - general fact sheet. Yellow fever, a hemorrhagic disease that is common in South America and sub-Saharan Africa, infects about 200,000 people per year and causes an estimated 30,000 deaths.

The city’s free black community, meanwhile, largely stayed behind and many were enlisted to help care for the sick.Among the mass exodus of some 20,000 Philadelphians—nearly half the city’s total population at the time—during the yellow fever epidemic were many of the city’s doctors, who were terrified of getting ill themselves. They covered their faces with handkerchiefs dipped in vinegar or smoked tobacco, which they thought would prevent them from breathing in contaminated air.Arch Street Wharf in Philadelphia, where some of the first cases were identified.By the end of August, as more and more people began dying from this mysterious affliction, wealthier residents of the nation’s capital were fleeing in droves. Yellow fever vaccine-associated viscerotropic disease: current perspectives.

New Orleans, Mobile, Savannah, and Charleston were major targets; Memphis suffered terribly in 1878. ScienceDirect ® is a registered trademark of Elsevier B.V.Yellow fever epidemics struck the United States repeatedly in the 18th and 19th centuries. Yellow fever epidemics caused terror, economic disruption, and some 100,000–150,000 deaths.

Alexander Hamilton contracted yellow fever early in the epidemic, and he and his family left the city for their summer home a few miles away.

If you are travelling to Africa, the Caribbean, Central or South America, you should be aware of the risk of yellow fever virus transmission and take the necessary precautions to protect yourself from infection.